Please wait...

HIPEC for peritoneal carcinomatosis: does an associated urologic procedure increase morbidity?

Want create site? Find Free WordPress Themes and plugins.

Honoré C(1), Souadka A, Goéré D, Dumont F, Deschamps F, Elias D.


Author information:

(1)Department of Surgical Oncology, Institut Gustave Roussy, Cancer Center, Villejuif, France.


PURPOSE: To report the incidence of urinary tract procedures performed during complete cytoreductive surgery (CCRS) plus intraperitoneal chemotherapy, and to report the types of procedure, specific morbidity, risk factors, and treatment.

METHODS: Data were extracted from a prospective database of patients with malignant peritoneal disease treated with CCRS plus intraperitoneal chemotherapy  who had undergone a resection or suture of the bladder, ureter, or kidney. Patients were eligible whatever the tumor origin.

RESULTS: Between 1994 and 2010, among the 598 patients treated with CCRS plus intraperitoneal chemotherapy, 48 (8%) had undergone a resection or suture in the  urinary tract. Procedures included 4 nephrectomies, 19 partial cystectomies, 8 surgically repaired bladder injuries, and 18 ureteral resections. Postoperative mortality was 4% and morbidity was 41%. Specific complications included 6 urinary fistulas (12%), two among the 27 bladder sutures (7%) and four among the 18 ureteral sutures (22%) (P = NS). In the multivariate analysis, the risk factors for urinary fistula were severe preoperative malnutrition (P = 0.05, relative risk [RR] = 7.3) and extensive peritoneal disease (peritoneal cancer index ≥20, P = 0.05, RR = 8.3). Urinary fistulas had been treated nonsurgically in most of the cases.

CONCLUSIONS: Associated urinary tract procedures had occurred in 8% of the cases  but did not greatly increase morbidity. Therefore, urinary tract involvement or injury are not contraindications to performing CCRS plus intraperitoneal chemotherapy. Fistulas had complicated only 12% of urinary sutures, mainly in cases of malnutrition or extensive peritoneal disease.


DOI: 10.1245/s10434-011-1820-2

PMID: 21638092  [Indexed for MEDLINE]


Ann Surg Oncol. 2012 Jan;19(1):104-9. doi: 10.1245/s10434-011-1820-2. Epub 2011 Jun 3.

Did you find apk for android? You can find new Free Android Games and apps.

Copyright by Digital Zone 2018. All rights reserved.